Pomelo fruit wastes are potentially valuable antioxidants, anti-inflammatories, antihypertensives, and antihyperglycemics

Abstract Grapefruit (G) parts contain abundant phenolic acids and flavonoids (PPNs FLVs). The wastes created from exocarps, mesocarps (G wastes, GW) waste blanching water (WBW) lead to a considerable loss of PPNs FLVs. Here, we assessed Buntan (CB), Hayata (CBH), Peiyu (CP) cultivars observed amounts ethanolic extracts GW (GWE) WBW contained gallic acid, protocatechuic chlorogenic caffeic ferulic coumaric naringin, hesperidin, diosmin, quercetin, hesperetin, nobiletin, tangeretin (GWC). GWE has previously been reported be relatively active antioxidant, anti-inflammatory (based on the expression TNF-α in Raw264.7 cells), antihypertensive, anti-hyperglycemic compound. IC 50 values for antihyperglycemic activity with α-amylase were as follows: CB (27.96 ± 0.03 mg/mL) < CP (28.13 0.19 CBH (41.60 0.16 mg/mL), those α-glucosidase (1.80 (2.97 0.29 (9.10 0.51 mg/mL). GWC upregulated Glut4 HepG2 cells, well insulin secretion capability, intracellular levels RIN-m5F it downregulated DPP4 cells. angiotensin-converting enzyme were: CBP (5.10 0.02 (7.24 0.65 (8.60 2.03 Our results indicate that FLVs present are worth reclaiming.